Nicola Simola Selected Research

2- furan- 2- yl- 7- 3- (4- (4- (4- methylpiperazine- 1- sulfonyl)phenylethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo- (1,5- c)pyrimdin- 5- ylamine)

9/2004

Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions.

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Nicola Simola Research Topics

Disease

18	Parkinson Disease (Parkinson's Disease) 01/2021 - 11/2005
10	Dyskinesias (Dyskinesia) 01/2018 - 11/2005
5	Tremor (Tremors) 03/2010 - 09/2004
4	Gliosis 01/2021 - 12/2018
4	Neuroinflammatory Diseases 01/2020 - 10/2014
3	Cognitive Dysfunction 01/2020 - 10/2014
3	Asphyxia (Suffocation) 01/2014 - 04/2010
2	Hyperglycemia 01/2019 - 01/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2020
1	Dysbiosis 09/2020
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2020
1	Narcolepsy 01/2020
1	Brain Diseases (Brain Disorder) 11/2019
1	Diabetes Mellitus 01/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Mental Disorders (Mental Disorder) 12/2018
1	Substance-Related Disorders (Drug Abuse) 08/2017
1	Disease Progression 08/2015
1	Amphetamine-Related Disorders (Addiction, Amphetamine) 03/2015
1	Depressive Disorder (Melancholia) 05/2011
1	Acidosis 05/2011
1	Glioma (Gliomas) 09/2008

Drug/Important Bio-Agent (IBA)

8	Levodopa (L Dopa)FDA LinkGeneric 04/2016 - 11/2005
7	Dopamine (Intropin)FDA LinkGeneric 01/2021 - 10/2006
6	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2018 - 09/2004
5	Tacrine (Cognex)FDA Link 03/2010 - 09/2004
3	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2021 - 10/2014
3	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2011
3	Niacinamide (Nicotinamide)FDA LinkGeneric 01/2018 - 04/2010
3	LigandsIBA 04/2016 - 09/2008
3	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 04/2016 - 10/2014
2	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2021 - 01/2020
2	Amphetamine (Amfetamine)FDA LinkGeneric 01/2021 - 08/2017
2	Pharmaceutical PreparationsIBA 01/2021 - 07/2007
2	CalciumIBA 01/2021 - 01/2020
2	Glial Fibrillary Acidic ProteinIBA 01/2021 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 09/2020 - 01/2012
2	Adenosine A2 Receptor AntagonistsIBA 01/2018 - 11/2005
2	NAD (NADH)IBA 01/2014 - 05/2011
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 10/2006 - 09/2004
2	5- amino- 7- (2- phenylethyl)- 2- (2- furyl)pyrazolo(4,3- e)- 1,2,4- triazolo(1,5- c)pyrimidineIBA 10/2006 - 09/2004
1	Neuroprotective AgentsIBA 09/2020
1	alpha-SynucleinIBA 09/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	SynucleinsIBA 01/2020
1	Psychotropic Drugs (Psychoactive Drugs)IBA 11/2019
1	polyolIBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	HexosaminesIBA 01/2019
1	Advanced Glycation End ProductsIBA 01/2019
1	Tenofovir (Viread)FDA Link 12/2018
1	Nevirapine (Viramune)FDA Link 12/2018
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2018
1	Serotonin Receptor Agonists (Serotonin Receptor Agonist)IBA 01/2018
1	eltoprazineIBA 04/2016
1	2- (2- furanyl)- 7- (2- (4- (4- (2- methoxyethoxy)phenyl)- 1- piperazinyl)ethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo(1,5- c)pyrimidine- 5- amineIBA 04/2016
1	Serotonin (5 Hydroxytryptamine)IBA 04/2016
1	Therapeutic UsesIBA 04/2016
1	Glutamic Acid (Glutamate)FDA Link 08/2015
1	Drug CombinationsIBA 08/2015
1	Dopamine Agonists (Dopamine Agonist)IBA 03/2015
1	Apomorphine FDA Link 03/2015
1	Uric Acid (Urate)IBA 11/2014
1	Poly (ADP-Ribose) Polymerase-1IBA 01/2014
1	CytokinesIBA 01/2014
1	Dopamine Receptors (Dopamine Receptor)IBA 10/2013
1	Adenosine (Adenocard)FDA LinkGeneric 01/2012
1	Adenosine Triphosphate (ATP)IBA 05/2011
1	Oxygen (Dioxygen)IBA 05/2011
1	gamma-Aminobutyric Acid (GABA)IBA 05/2011
1	Anti-Anxiety Agents (Anxiolytics)IBA 05/2011
1	NeurosteroidsIBA 05/2011
1	Investigational DrugsIBA 11/2010
1	8-ethoxy- 9-ethyladenineIBA 03/2010
1	PK 11195 (PK11195)IBA 09/2008
1	SteroidsIBA 09/2008
1	2- n- butyl- 9- methyl- 8- (1,2,3)triazol- 2- yl- 9H- purin- 6- ylamineIBA 07/2007
1	Oxidopamine (6 Hydroxydopamine)IBA 04/2007
1	NeurotoxinsIBA 04/2007
1	Pilocarpine (Ocusert)FDA LinkGeneric 10/2006
1	Purinergic P1 Receptors (Adenosine Receptor)IBA 10/2006
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 10/2006
1	Cholinergic Agents (Cholinergics)IBA 10/2006
1	istradefyllineIBA 11/2005
1	2- furan- 2- yl- 7- 3- (4- (4- (4- methylpiperazine- 1- sulfonyl)phenylethyl)- 7H- pyrazolo(4,3- e)(1,2,4)triazolo- (1,5- c)pyrimdin- 5- ylamine)IBA 09/2004

Therapy/Procedure

9	Therapeutics 01/2021 - 11/2005
1	Deep Brain Stimulation 08/2014
1	Resuscitation 05/2011
1	Drug Therapy (Chemotherapy) 11/2010
1	Traditional Medicine (Folk Remedies) 02/2009